Joint Biology

Concurrent Session 4

Date/Time: Friday, May 1, 2020 - 2:00 PM to 3:30 PM
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Mass Spectrometry In Matrisome Characterization

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyper-production or alteration of the composition of the ECM cause or accompany numerous pathologies including musculo-skeletal diseases, cancers, and fibroses. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities. In the first part of my talk, I will describe our latest advances in bioinformatics and mass-spectrometry-based proteomics to define the in silico and in vivo “matrisome” of normal and diseased tissues. I will then discuss how these approaches can be used to characterize the ECM composition of normal and diseased samples and lead to the identification of 1) novel proteins playing causal role in the etiology of diseases, and 2) ECM biomarkers distinguishing normal and diseased tissues and of prognostic value to patients. In the last part of my talk, I will discuss the upcoming release of MatrisomeDB, a compendium of proteomic data on the ECM of normal and diseased tissues.